EGFR

ENSG00000146648 - H. sapiens

Pathways

Go term Description
GO:0001948 glycoprotein binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0048408 epidermal growth factor binding
GO:0051015 actin filament binding
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:0030235 nitric-oxide synthase regulator activity
GO:0019904 protein domain specific binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
CETUXIMAB Epidermal growth factor receptor erbB1 inhibitor
ERLOTINIB Epidermal growth factor receptor erbB1 inhibitor
GEFITINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PANITUMUMAB Epidermal growth factor receptor erbB1 inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
glioma
NSCLC

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000113758 DBN1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.981269 View
ENSG00000125656 CLPP ENSG00000146648 EGFR H. sapiens SDL Slorth 0.981269 View
ENSG00000114346 ECT2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.981234 View
ENSG00000146648 EGFR ENSG00000152684 PELO H. sapiens SDL Slorth 0.981229 View
ENSG00000146648 EGFR ENSG00000160255 ITGB2 H. sapiens SDL Slorth 0.981209 View
ENSG00000112294 ALDH5A1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.981203 View
ENSG00000146648 EGFR ENSG00000178921 PFAS H. sapiens SDL Slorth 0.981201 View
ENSG00000082146 STRADB ENSG00000146648 EGFR H. sapiens SDL Slorth 0.981181 View
ENSG00000146648 EGFR ENSG00000238134 EHMT2 H. sapiens SDL Slorth 0.981167 View
ENSG00000146648 EGFR ENSG00000155097 ATP6V1C1 H. sapiens SDL Slorth 0.981166 View
ENSG00000146648 EGFR ENSG00000177189 RPS6KA3 H. sapiens SDL Slorth 0.981166 View
ENSG00000106003 LFNG ENSG00000146648 EGFR H. sapiens SDL Slorth 0.981163 View
ENSG00000067715 SYT1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.981161 View
ENSG00000146648 EGFR ENSG00000185950 IRS2 H. sapiens SDL Slorth 0.981142 View
ENSG00000146648 EGFR ENSG00000152484 USP12 H. sapiens SDL Slorth 0.98113 View
ENSG00000115232 ITGA4 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.981128 View
ENSG00000033327 GAB2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.981125 View
ENSG00000146648 EGFR ENSG00000196628 TCF4 H. sapiens SDL Slorth 0.981121 View
ENSG00000121057 AKAP1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.981112 View
ENSG00000146648 EGFR ENSG00000184304 PRKD1 H. sapiens SDL Slorth 0.981109 View
ENSG00000146648 EGFR ENSG00000204120 GIGYF2 H. sapiens SDL Slorth 0.981081 View
ENSG00000146648 EGFR ENSG00000198033 TUBA3C H. sapiens SDL Slorth 0.981072 View
ENSG00000008256 CYTH3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.981017 View
ENSG00000105438 KDELR1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.981015 View
ENSG00000146648 EGFR ENSG00000188021 UBQLN2 H. sapiens SDL Slorth 0.980973 View
ENSG00000146648 EGFR ENSG00000146872 TLK2 H. sapiens SDL Slorth 0.980942 View
ENSG00000103522 IL21R ENSG00000146648 EGFR H. sapiens SDL Slorth 0.980932 View
ENSG00000146648 EGFR ENSG00000182872 RBM10 H. sapiens SDL Slorth 0.980924 View
ENSG00000101844 ATG4A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.980907 View
ENSG00000146648 EGFR ENSG00000166192 SENP8 H. sapiens SDL Slorth 0.980886 View
ENSG00000011132 APBA3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.980872 View
ENSG00000146648 EGFR ENSG00000153201 RANBP2 H. sapiens SDL Slorth 0.98087 View
ENSG00000146648 EGFR ENSG00000154767 XPC H. sapiens SDL Slorth 0.980865 View
ENSG00000146648 EGFR ENSG00000173327 MAP3K11 H. sapiens SDL Slorth 0.980858 View
ENSG00000146648 EGFR ENSG00000152104 PTPN14 H. sapiens SDL Slorth 0.980849 View
ENSG00000146648 EGFR ENSG00000198947 DMD H. sapiens SDL Slorth 0.980832 View
ENSG00000135966 TGFBRAP1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.980817 View
ENSG00000070476 ZXDC ENSG00000146648 EGFR H. sapiens SDL Slorth 0.980804 View
ENSG00000005882 PDK2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.980804 View
ENSG00000118900 UBN1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.980804 View