JAK1

ENSG00000162434 - H. sapiens

Pathways

Go term Description
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005102 receptor binding
GO:0005131 growth hormone receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0031730 CCR5 chemokine receptor binding
GO:0046872 metal ion binding

Drugs

Drug name Description
RUXOLITINIB Tyrosine-protein kinase JAK2 inhibitor
TOFACITINIB Janus Kinase (JAK) inhibitor

Diseases

Disease Name
ALL

Orthologs

Gene Organism
hop D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000112592 TBP ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.969278 View
ENSG00000121022 COPS5 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.96908 View
ENSG00000096384 HSP90AB1 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.969061 View
ENSG00000162434 JAK1 ENSG00000169800 RBMY1F H. sapiens SDL Slorth 0.968713 View
ENSG00000142192 APP ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.96859 View
ENSG00000085999 RAD54L ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.968476 View
ENSG00000077279 DCX ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.968471 View
ENSG00000072163 LIMS2 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.968379 View
ENSG00000159692 CTBP1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.968217 View
ENSG00000133124 IRS4 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.968196 View
ENSG00000097007 ABL1 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.967967 View
ENSG00000162434 JAK1 ENSG00000168646 AXIN2 H. sapiens SDL Slorth 0.967909 View
ENSG00000162434 JAK1 ENSG00000183791 TCEB3C H. sapiens SDL Slorth 0.967863 View
ENSG00000162434 JAK1 ENSG00000184012 TMPRSS2 H. sapiens SDL Slorth 0.967746 View
ENSG00000077092 RARB ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.967699 View
ENSG00000162434 JAK1 ENSG00000173404 INSM1 H. sapiens SDL Slorth 0.96766 View
ENSG00000069869 NEDD4 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.9673 View
ENSG00000102683 SGCG ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.967103 View
ENSG00000131759 RARA ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.967076 View
ENSG00000116016 EPAS1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.967039 View
ENSG00000137693 YAP1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.966974 View
ENSG00000113575 PPP2CA ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.966717 View
ENSG00000112062 MAPK14 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.966694 View
ENSG00000135486 HNRNPA1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.966657 View
ENSG00000121879 PIK3CA ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.966569 View
ENSG00000021574 SPAST ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.966304 View
ENSG00000130766 SESN2 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.966087 View
ENSG00000137073 UBAP2 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.966045 View
ENSG00000082701 GSK3B ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.965915 View
ENSG00000100239 PPP6R2 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.96591 View
ENSG00000079156 OSBPL6 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.96584 View
ENSG00000113240 CLK4 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.965649 View
ENSG00000101266 CSNK2A1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.96551 View
ENSG00000162434 JAK1 ENSG00000175093 SPSB4 H. sapiens SDL Slorth 0.965364 View
ENSG00000162434 JAK1 ENSG00000171621 SPSB1 H. sapiens SDL Slorth 0.965364 View
ENSG00000114554 PLXNA1 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.965343 View
ENSG00000132646 PCNA ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.965325 View
ENSG00000101966 XIAP ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.965294 View
ENSG00000061273 HDAC7 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.965146 View
ENSG00000078747 ITCH ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.965144 View