KIT

ENSG00000157404 - H. sapiens

Pathways

Go term Description
GO:0002020 protease binding
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0005020 stem cell factor receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0019955 cytokine binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity

Drugs

Drug name Description
CABOZANTINIB
DASATINIB Tyrosine-protein kinase ABL inhibitor
IMATINIB Tyrosine-protein kinase ABL inhibitor
LENVATINIB
PAZOPANIB Tyrosine-protein kinase LCK inhibitor
PONATINIB Tyrosine-protein kinase ABL inhibitor
REGORAFENIB Tyrosine-protein kinase ABL inhibitor
SORAFENIB Serine/threonine-protein kinase RAF inhibitor
SUNITINIB Macrophage colony stimulating factor receptor inhibitor

Diseases

Disease Name
GIST
AML
TGCT
mastocytosis
mucosal melanoma
epithelioma

Orthologs

Gene Organism
Pvr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000148677 ANKRD1 ENSG00000157404 KIT H. sapiens SDL Slorth 0.924748 View
ENSG00000099365 STX1B ENSG00000157404 KIT H. sapiens SDL Slorth 0.924566 View
ENSG00000113712 CSNK1A1 ENSG00000157404 KIT H. sapiens SSL Slorth 0.924329 View
ENSG00000116016 EPAS1 ENSG00000157404 KIT H. sapiens SSL Slorth 0.924298 View
ENSG00000135597 REPS1 ENSG00000157404 KIT H. sapiens SDL Slorth 0.924014 View
ENSG00000104140 RHOV ENSG00000157404 KIT H. sapiens SDL Slorth 0.923675 View
ENSG00000112679 DUSP22 ENSG00000157404 KIT H. sapiens SDL Slorth 0.923467 View
ENSG00000157404 KIT ENSG00000185697 MYBL1 H. sapiens SDL Slorth 0.92344 View
ENSG00000123612 ACVR1C ENSG00000157404 KIT H. sapiens SDL Slorth 0.92343 View
ENSG00000136238 RAC1 ENSG00000157404 KIT H. sapiens SDL Slorth 0.923411 View
ENSG00000085840 ORC1 ENSG00000157404 KIT H. sapiens SSL Slorth 0.923208 View
ENSG00000157404 KIT ENSG00000163513 TGFBR2 H. sapiens SDL Slorth 0.922733 View
ENSG00000110031 LPXN ENSG00000157404 KIT H. sapiens SDL Slorth 0.922663 View
ENSG00000072062 PRKACA ENSG00000157404 KIT H. sapiens SSL Slorth 0.922659 View
ENSG00000090889 KIF4A ENSG00000157404 KIT H. sapiens SDL Slorth 0.922538 View
ENSG00000111540 RAB5B ENSG00000157404 KIT H. sapiens SDL Slorth 0.922106 View
ENSG00000157404 KIT ENSG00000163932 PRKCD H. sapiens SDL Slorth 0.922102 View
ENSG00000110048 OSBP ENSG00000157404 KIT H. sapiens SDL Slorth 0.922012 View
ENSG00000137166 FOXP4 ENSG00000157404 KIT H. sapiens SDL Slorth 0.922003 View
ENSG00000115216 NRBP1 ENSG00000157404 KIT H. sapiens SDL Slorth 0.922003 View
ENSG00000114861 FOXP1 ENSG00000157404 KIT H. sapiens SDL Slorth 0.922003 View
ENSG00000005882 PDK2 ENSG00000157404 KIT H. sapiens SDL Slorth 0.922003 View
ENSG00000077935 SMC1B ENSG00000157404 KIT H. sapiens SDL Slorth 0.921994 View
ENSG00000151247 EIF4E ENSG00000157404 KIT H. sapiens SSL Slorth 0.92189 View
ENSG00000157404 KIT ENSG00000178562 CD28 H. sapiens SDL Slorth 0.921866 View
ENSG00000111049 MYF5 ENSG00000157404 KIT H. sapiens SDL Slorth 0.921835 View
ENSG00000125656 CLPP ENSG00000157404 KIT H. sapiens SDL Slorth 0.921594 View
ENSG00000118900 UBN1 ENSG00000157404 KIT H. sapiens SDL Slorth 0.921594 View
ENSG00000048540 LMO3 ENSG00000157404 KIT H. sapiens SDL Slorth 0.921594 View
ENSG00000125967 NECAB3 ENSG00000157404 KIT H. sapiens SDL Slorth 0.921594 View
ENSG00000108773 KAT2A ENSG00000157404 KIT H. sapiens SDL Slorth 0.921476 View
ENSG00000077380 DYNC1I2 ENSG00000157404 KIT H. sapiens SDL Slorth 0.921451 View
ENSG00000065559 MAP2K4 ENSG00000157404 KIT H. sapiens SSL Slorth 0.921227 View
ENSG00000044574 HSPA5 ENSG00000157404 KIT H. sapiens SSL Slorth 0.921204 View
ENSG00000130703 OSBPL2 ENSG00000157404 KIT H. sapiens SDL Slorth 0.921157 View
ENSG00000067829 IDH3G ENSG00000157404 KIT H. sapiens SDL Slorth 0.921041 View
ENSG00000114554 PLXNA1 ENSG00000157404 KIT H. sapiens SDL Slorth 0.920971 View
ENSG00000100239 PPP6R2 ENSG00000157404 KIT H. sapiens SDL Slorth 0.920949 View
ENSG00000112319 EYA4 ENSG00000157404 KIT H. sapiens SDL Slorth 0.920858 View
ENSG00000154997 SEPT14 ENSG00000157404 KIT H. sapiens SDL Slorth 0.920818 View