MAP2K1

ENSG00000169032 - H. sapiens

Pathways

Go term Description
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004702 signal transducer, downstream of receptor, with serine/threonine kinase activity
GO:0004708 MAP kinase kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004728 signal transducer, downstream of receptor, with protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0019901 protein kinase binding
GO:0043539 protein serine/threonine kinase activator activity
GO:0047485 protein N-terminus binding

Drugs

Drug name Description
TRAMETINIB Dual specificity mitogen-activated protein kinase kinase 2 inhibitor

Diseases

Disease Name
NSCLC
melanoma
colorectal

Orthologs

Gene Organism
PBS2 S. cerevisiae
mek-2 C. elegans
Dsor1 D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000132155 RAF1 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.972706 View
ENSG00000080824 HSP90AA1 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.97164 View
ENSG00000110395 CBL ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.970993 View
ENSG00000169032 MAP2K1 ENSG00000169083 AR H. sapiens SDL Slorth 0.970467 View
ENSG00000109670 FBXW7 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.970464 View
ENSG00000164924 YWHAZ ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.970012 View
ENSG00000169032 MAP2K1 ENSG00000186908 ZDHHC17 H. sapiens SDL Slorth 0.969744 View
ENSG00000141510 TP53 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.969648 View
ENSG00000169032 MAP2K1 ENSG00000176720 BOK H. sapiens SDL Slorth 0.969229 View
ENSG00000091831 ESR1 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.968002 View
ENSG00000133703 KRAS ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.967483 View
ENSG00000169032 MAP2K1 ENSG00000169926 KLF13 H. sapiens SDL Slorth 0.967228 View
ENSG00000135486 HNRNPA1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.966703 View
ENSG00000096384 HSP90AB1 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.96626 View
ENSG00000146648 EGFR ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.966123 View
ENSG00000106588 PSMA2 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.96597 View
ENSG00000112592 TBP ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.965491 View
ENSG00000169032 MAP2K1 ENSG00000204103 MAFB H. sapiens SDL Slorth 0.965205 View
ENSG00000112062 MAPK14 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.964831 View
ENSG00000101266 CSNK2A1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.964799 View
ENSG00000121022 COPS5 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.964727 View
ENSG00000127445 PIN1 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.964291 View
ENSG00000169032 MAP2K1 ENSG00000185896 LAMP1 H. sapiens SDL Slorth 0.963729 View
ENSG00000123374 CDK2 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.963719 View
ENSG00000159352 PSMD4 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.963175 View
ENSG00000141736 ERBB2 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.962989 View
ENSG00000168610 STAT3 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.962939 View
ENSG00000113558 SKP1 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.962869 View
ENSG00000100028 SNRPD3 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.962865 View
ENSG00000116030 SUMO1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.962857 View
ENSG00000096717 SIRT1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.962656 View
ENSG00000055130 CUL1 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.962489 View
ENSG00000129084 PSMA1 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.962327 View
ENSG00000169032 MAP2K1 ENSG00000182511 FES H. sapiens SDL Slorth 0.962047 View
ENSG00000141646 SMAD4 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.961836 View
ENSG00000103275 UBE2I ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.961443 View
ENSG00000169032 MAP2K1 ENSG00000197122 SRC H. sapiens SDL Slorth 0.961317 View
ENSG00000169032 MAP2K1 ENSG00000175376 EIF1AD H. sapiens SDL Slorth 0.961028 View
ENSG00000169032 MAP2K1 ENSG00000184937 WT1 H. sapiens SDL Slorth 0.960892 View
ENSG00000165119 HNRNPK ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.960707 View