MAP2K2

ENSG00000126934 - H. sapiens

Pathways

Go term Description
GO:0004674 protein serine/threonine kinase activity
GO:0004702 signal transducer, downstream of receptor, with serine/threonine kinase activity
GO:0004708 MAP kinase kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0030165 PDZ domain binding
GO:0043539 protein serine/threonine kinase activator activity
GO:0046872 metal ion binding
GO:0097110 scaffold protein binding

Drugs

Drug name Description
TRAMETINIB Dual specificity mitogen-activated protein kinase kinase 2 inhibitor

Diseases

Disease Name
NSCLC
melanoma

Orthologs

Gene Organism
PBS2 S. cerevisiae
mek-2 C. elegans
Dsor1 D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000126934 MAP2K2 ENSG00000183735 TBK1 H. sapiens SSL Slorth 0.849486 View
ENSG00000087586 AURKA ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.849456 View
ENSG00000121774 KHDRBS1 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.84686 View
ENSG00000113712 CSNK1A1 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.84501 View
ENSG00000126934 MAP2K2 ENSG00000181163 NPM1 H. sapiens SSL Slorth 0.840586 View
ENSG00000093009 CDC45 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.838888 View
ENSG00000126934 MAP2K2 ENSG00000254087 LYN H. sapiens SSL Slorth 0.836686 View
ENSG00000126934 MAP2K2 ENSG00000165731 RET H. sapiens SSL Slorth 0.836333 View
ENSG00000114742 WDR48 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.835823 View
ENSG00000061938 TNK2 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.832882 View
ENSG00000096968 JAK2 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.831751 View
ENSG00000105568 PPP2R1A ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.831347 View
ENSG00000004897 CDC27 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.830842 View
ENSG00000126934 MAP2K2 ENSG00000198625 MDM4 H. sapiens SSL Slorth 0.830421 View
ENSG00000001626 CFTR ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.829958 View
ENSG00000126934 MAP2K2 ENSG00000149554 CHEK1 H. sapiens SSL Slorth 0.829329 View
ENSG00000126934 MAP2K2 ENSG00000166851 PLK1 H. sapiens SSL Slorth 0.828565 View
ENSG00000126934 MAP2K2 ENSG00000197442 MAP3K5 H. sapiens SSL Slorth 0.827137 View
ENSG00000126934 MAP2K2 ENSG00000134982 APC H. sapiens SSL Slorth 0.824646 View
ENSG00000126934 MAP2K2 ENSG00000168283 BMI1 H. sapiens SSL Slorth 0.824101 View
ENSG00000126934 MAP2K2 ENSG00000134086 VHL H. sapiens SSL Slorth 0.823853 View
ENSG00000094804 CDC6 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.823759 View
ENSG00000072518 MARK2 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.823554 View
ENSG00000044574 HSPA5 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.822738 View
ENSG00000126934 MAP2K2 ENSG00000167513 CDT1 H. sapiens SSL Slorth 0.821929 View
ENSG00000126934 MAP2K2 ENSG00000186716 BCR H. sapiens SSL Slorth 0.818429 View
ENSG00000005007 UPF1 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.818411 View
ENSG00000126934 MAP2K2 ENSG00000153147 SMARCA5 H. sapiens SSL Slorth 0.817943 View
ENSG00000126934 MAP2K2 ENSG00000166501 PRKCB H. sapiens SSL Slorth 0.817214 View
ENSG00000126934 MAP2K2 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.816199 View
ENSG00000100387 RBX1 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.815913 View
ENSG00000117748 RPA2 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.813149 View
ENSG00000006451 RALA ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.811714 View
ENSG00000103479 RBL2 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.81165 View
ENSG00000102978 POLR2C ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.809844 View
ENSG00000126934 MAP2K2 ENSG00000162367 TAL1 H. sapiens SSL Slorth 0.808113 View
ENSG00000120438 TCP1 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.808111 View
ENSG00000121481 RNF2 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.808035 View
ENSG00000126934 MAP2K2 ENSG00000138376 BARD1 H. sapiens SSL Slorth 0.807304 View
ENSG00000126934 MAP2K2 ENSG00000157404 KIT H. sapiens SSL Slorth 0.806511 View