TOP2A

ENSG00000131747 - H. sapiens

Pathways

Go term Description
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0008094 DNA-dependent ATPase activity
GO:0008144 drug binding
GO:0008301 DNA binding, bending
GO:0019899 enzyme binding
GO:0042803 protein homodimerization activity
GO:0042826 histone deacetylase binding
GO:0043130 ubiquitin binding
GO:0046982 protein heterodimerization activity

Drugs

Drug name Description
DAUNORUBICIN DNA topoisomerase II alpha inhibitor
DOXORUBICIN DNA topoisomerase II alpha inhibitor
EPIRUBICIN
ETOPOSIDE DNA topoisomerase II inhibitor
ETOPOSIDE PHOSPHATE DNA topoisomerase II alpha inhibitor
IDARUBICIN DNA topoisomerase II alpha inhibitor
MITOXANTRONE
PODOFILOX
TENIPOSIDE DNA topoisomerase II inhibitor
VALRUBICIN DNA topoisomerase II alpha inhibitor

Diseases

No diseases in record

Orthologs

Gene Organism
TOP2 S. cerevisiae
cin-4 C. elegans
top-2 C. elegans

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000131747 TOP2A ENSG00000143344 RGL1 H. sapiens SDL Slorth 0.941658 View
ENSG00000131747 TOP2A ENSG00000159496 RGL4 H. sapiens SDL Slorth 0.941658 View
ENSG00000131747 TOP2A ENSG00000143256 PFDN2 H. sapiens SDL Slorth 0.941604 View
ENSG00000131747 TOP2A ENSG00000276618 RAD17 H. sapiens SDL Slorth 0.941524 View
ENSG00000106290 TAF6 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.941435 View
ENSG00000131747 TOP2A ENSG00000136450 SRSF1 H. sapiens SSL Slorth 0.941337 View
ENSG00000131747 TOP2A ENSG00000175792 RUVBL1 H. sapiens SSL Slorth 0.941272 View
ENSG00000131747 TOP2A ENSG00000163932 PRKCD H. sapiens SSL Slorth 0.941136 View
ENSG00000131747 TOP2A ENSG00000175093 SPSB4 H. sapiens SDL Slorth 0.940716 View
ENSG00000131747 TOP2A ENSG00000171621 SPSB1 H. sapiens SDL Slorth 0.940716 View
ENSG00000131747 TOP2A ENSG00000196591 HDAC2 H. sapiens SSL Slorth 0.940679 View
ENSG00000131747 TOP2A ENSG00000137486 ARRB1 H. sapiens SSL Slorth 0.940491 View
ENSG00000131747 TOP2A ENSG00000180008 SOCS4 H. sapiens SDL Slorth 0.940489 View
ENSG00000100387 RBX1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.94045 View
ENSG00000131747 TOP2A ENSG00000135829 DHX9 H. sapiens SSL Slorth 0.940304 View
ENSG00000108840 HDAC5 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.94024 View
ENSG00000131747 TOP2A ENSG00000154447 SH3RF1 H. sapiens SDL Slorth 0.940239 View
ENSG00000108424 KPNB1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.940173 View
ENSG00000131747 TOP2A ENSG00000188130 MAPK12 H. sapiens SDL Slorth 0.939853 View
ENSG00000131747 TOP2A ENSG00000185386 MAPK11 H. sapiens SDL Slorth 0.939699 View
ENSG00000131747 TOP2A ENSG00000147316 MCPH1 H. sapiens SDL Slorth 0.939503 View
ENSG00000131747 TOP2A ENSG00000171150 SOCS5 H. sapiens SDL Slorth 0.939472 View
ENSG00000131747 TOP2A ENSG00000166851 PLK1 H. sapiens SSL Slorth 0.939463 View
ENSG00000131747 TOP2A ENSG00000143776 CDC42BPA H. sapiens SDL Slorth 0.939444 View
ENSG00000080986 NDC80 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.939427 View
ENSG00000131747 TOP2A ENSG00000184634 MED12 H. sapiens SSL Slorth 0.939334 View
ENSG00000131747 TOP2A ENSG00000137693 YAP1 H. sapiens SSL Slorth 0.939237 View
ENSG00000061938 TNK2 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.939226 View
ENSG00000131747 TOP2A ENSG00000283094 PTEN H. sapiens SSL Slorth 0.939211 View
ENSG00000104695 PPP2CB ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.939139 View
ENSG00000131747 TOP2A ENSG00000170345 FOS H. sapiens SDL Slorth 0.939045 View
ENSG00000131747 TOP2A ENSG00000163660 CCNL1 H. sapiens SDL Slorth 0.939005 View
ENSG00000112531 QKI ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.938772 View
ENSG00000131747 TOP2A ENSG00000168496 FEN1 H. sapiens SSL Slorth 0.938726 View
ENSG00000131747 TOP2A ENSG00000159259 CHAF1B H. sapiens SDL Slorth 0.938554 View
ENSG00000114423 CBLB ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.938439 View
ENSG00000131747 TOP2A ENSG00000185379 RAD51D H. sapiens SDL Slorth 0.938385 View
ENSG00000075089 ACTR6 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.938312 View
ENSG00000131747 TOP2A ENSG00000140464 PML H. sapiens SSL Slorth 0.938018 View
ENSG00000109332 UBE2D3 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.937987 View