MECOM - TOP1

SSL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
MECOM	ENSG00000085276	AML CML MDS	No drugs in record	DNA binding transcription factor activity, sequence-specific DNA binding protein binding histone-lysine N-methyltransferase activity metal ion binding	COM2 (S. cerevisiae) MSN2 (S. cerevisiae)
TOP1	ENSG00000198900	AML*	IRINOTECAN	core promoter sequence-specific DNA binding DNA binding chromatin binding DNA topoisomerase type I activity protein binding isomerase activity DNA topoisomerase activity	TOP1 (S. cerevisiae) top-1 (C. elegans) Top1 (D. melanogaster)