FGFR1 - SMAD2

H. sapiens

SSL interaction

Identifiers

Gene Name Gene ID Diseases Drugs GO terms Orthologs
FGFR1 ENSG00000077782 MPN
NHL
salivary adenoma
LENVATINIB
NINTEDANIB
PAZOPANIB
PONATINIB
REGORAFENIB
protein tyrosine kinase activity
fibroblast growth factor-activated receptor activity
Ras guanyl-nucleotide exchange factor activity
protein binding
ATP binding
heparin binding
1-phosphatidylinositol-3-kinase activity
fibroblast growth factor binding
identical protein binding
protein homodimerization activity
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
egl-15 (C. elegans)
htl (D. melanogaster)
SMAD2 ENSG00000175387 colorectal carcinoma
hepatocellular carcinoma

No drugs in record

RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
chromatin binding
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
transforming growth factor beta receptor binding
protein binding
transcription factor binding
phosphatase binding
transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
ubiquitin protein ligase binding
activating transcription factor binding
type I transforming growth factor beta receptor binding
enhancer binding
protein homodimerization activity
SMAD binding
metal ion binding
protein heterodimerization activity
co-SMAD binding
I-SMAD binding
R-SMAD binding
DNA binding
sma-3 (C. elegans)
sma-2 (C. elegans)