HIF1A - MAP2K2

H. sapiens

SDL interaction

Identifiers

Gene Name Gene ID Diseases Drugs GO terms Orthologs
HIF1A ENSG00000100644 endometrioid carcinoma
glioblastoma
colorectal
renal
lung
pancreatic

No drugs in record

transcription factor activity, transcription factor binding
transcription factor activity, RNA polymerase II transcription factor binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
protein binding
transcription factor binding
enzyme binding
protein kinase binding
ubiquitin protein ligase binding
histone acetyltransferase binding
nuclear hormone receptor binding
histone deacetylase binding
protein heterodimerization activity
Hsp90 protein binding
sequence-specific DNA binding
hif-1 (C. elegans)
MAP2K2 ENSG00000126934 NSCLC
melanoma
TRAMETINIB
protein serine/threonine kinase activity
signal transducer, downstream of receptor, with serine/threonine kinase activity
MAP kinase kinase activity
protein serine/threonine/tyrosine kinase activity
protein tyrosine kinase activity
protein binding
ATP binding
PDZ domain binding
protein serine/threonine kinase activator activity
metal ion binding
scaffold protein binding
PBS2 (S. cerevisiae)
mek-2 (C. elegans)
Dsor1 (D. melanogaster)