PICALM - GRB2

SDL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
PICALM	ENSG00000073921	T-ALL AML	No drugs in record	protein binding 1-phosphatidylinositol binding clathrin binding clathrin heavy chain binding clathrin adaptor activity cadherin binding involved in cell-cell adhesion	YAP1801 (S. cerevisiae) YAP1802 (S. cerevisiae) unc-11 (C. elegans) lap (D. melanogaster)
GRB2	ENSG00000177885	No diseases in record	No drugs in record	phosphotyrosine residue binding SH3/SH2 adaptor activity Ras guanyl-nucleotide exchange factor activity epidermal growth factor receptor binding neurotrophin TRKA receptor binding protein binding 1-phosphatidylinositol-3-kinase activity SH3 domain binding protein kinase binding protein phosphatase binding identical protein binding insulin receptor substrate binding ephrin receptor binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity	sem-5 (C. elegans)