FLT4 - PTPN11

SDL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
FLT4	ENSG00000037280	soft tissue sarcoma	AXITINIB LENVATINIB NINTEDANIB PAZOPANIB REGORAFENIB SORAFENIB SUNITINIB VANDETANIB	transmembrane receptor protein tyrosine kinase activity vascular endothelial growth factor-activated receptor activity protein binding ATP binding growth factor binding protein phosphatase binding	Pvr (D. melanogaster)
PTPN11	ENSG00000179295	JMML AML MDS	No drugs in record	phosphoprotein phosphatase activity protein tyrosine phosphatase activity non-membrane spanning protein tyrosine phosphatase activity SH3/SH2 adaptor activity insulin receptor binding protein binding 1-phosphatidylinositol-3-kinase activity protein domain specific binding receptor tyrosine kinase binding D1 dopamine receptor binding phospholipase binding insulin receptor substrate binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity cell adhesion molecule binding peptide hormone receptor binding	PTP1 (S. cerevisiae) ptp-2 (C. elegans) csw (D. melanogaster)