SMAD4 - DHFR

H. sapiens

SSL interaction

Identifiers

Gene Name Gene ID Diseases Drugs GO terms Orthologs
SMAD4 ENSG00000141646 colorectal
pancreatic
small intestine
gastrointestinal polyp

No drugs in record

RNA polymerase II core promoter proximal region sequence-specific DNA binding
core promoter proximal region sequence-specific DNA binding
transcription factor activity, RNA polymerase II transcription factor binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II transcription factor binding
chromatin binding
protein binding
collagen binding
transforming growth factor beta receptor, common-partner cytoplasmic mediator activity
identical protein binding
protein homodimerization activity
transcription regulatory region DNA binding
metal ion binding
protein heterodimerization activity
I-SMAD binding
R-SMAD binding
transcription factor activity, protein binding
DNA binding
transcription factor activity, sequence-specific DNA binding
sequence-specific DNA binding
Med (D. melanogaster)
DHFR ENSG00000228716

No diseases in record

METHOTREXATE
PEMETREXED
PRALATREXATE
mRNA binding
dihydrofolate reductase activity
folic acid binding
drug binding
folate reductase activity
methotrexate binding
NADPH binding
protein binding
NADP binding
DFR1 (S. cerevisiae)