DOT1L - ERBB2

SSL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
DOT1L	ENSG00000104885	No diseases in record	No drugs in record	DNA binding protein binding histone-lysine N-methyltransferase activity histone methyltransferase activity (H3-K79 specific) histone methyltransferase activity	DOT1 (S. cerevisiae) gpp (D. melanogaster)
ERBB2	ENSG00000141736	breast ovarian other tumour types NSCLC gastric	AFATINIB LAPATINIB PERTUZUMAB TRASTUZUMAB TRASTUZUMAB EMTANSINE VANDETANIB	RNA polymerase I core binding protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity signal transducer, downstream of receptor, with protein tyrosine kinase activity transmembrane signaling receptor activity Ras guanyl-nucleotide exchange factor activity protein binding ATP binding protein C-terminus binding protein phosphatase binding identical protein binding ErbB-3 class receptor binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity protein heterodimerization activity protein dimerization activity growth factor binding	let-23 (C. elegans) Egfr (D. melanogaster)