ERBB2 - PGAM5

SSL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
ERBB2	ENSG00000141736	breast ovarian other tumour types NSCLC gastric	AFATINIB LAPATINIB PERTUZUMAB TRASTUZUMAB TRASTUZUMAB EMTANSINE VANDETANIB	RNA polymerase I core binding protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity signal transducer, downstream of receptor, with protein tyrosine kinase activity transmembrane signaling receptor activity Ras guanyl-nucleotide exchange factor activity protein binding ATP binding protein C-terminus binding protein phosphatase binding identical protein binding ErbB-3 class receptor binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity protein heterodimerization activity protein dimerization activity growth factor binding	let-23 (C. elegans) Egfr (D. melanogaster)
PGAM5	ENSG00000247077	No diseases in record	No drugs in record	GTPase activator activity signal transducer, downstream of receptor, with serine/threonine phosphatase activity phosphatase activity protein complex binding protein serine/threonine kinase activator activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity phosphoglycerate mutase activity kinase binding protein binding	Pgam5 (D. melanogaster) Pgam5-2 (D. melanogaster)