LEF1

ENSG00000138795 - H. sapiens

Pathways

Go term Description
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0008134 transcription factor binding
GO:0008301 DNA binding, bending
GO:0030284 estrogen receptor activity
GO:0030331 estrogen receptor binding
GO:0035326 enhancer binding
GO:0042393 histone binding
GO:0042826 histone deacetylase binding
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0045295 gamma-catenin binding
GO:0070016 armadillo repeat domain binding
GO:0070742 C2H2 zinc finger domain binding

Drugs

No drugs in record

Diseases

Disease Name
B-ALL
T-ALL
eyelid sebaceous carcinoma
AML
lymphomas

Orthologs

Gene Organism
pop-1 C. elegans
pan D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000134308 YWHAQ ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.768886 View
ENSG00000132170 PPARG ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.767006 View
ENSG00000138795 LEF1 ENSG00000169750 RAC3 H. sapiens SSL Slorth 0.766263 View
ENSG00000099817 POLR2E ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.764995 View
ENSG00000067560 RHOA ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.764409 View
ENSG00000089159 PXN ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.764399 View
ENSG00000127022 CANX ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.764205 View
ENSG00000138795 LEF1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.762128 View
ENSG00000107581 EIF3A ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.759145 View
ENSG00000138795 LEF1 ENSG00000154229 PRKCA H. sapiens SSL Slorth 0.759082 View
ENSG00000138795 LEF1 ENSG00000150093 ITGB1 H. sapiens SSL Slorth 0.756713 View
ENSG00000138795 LEF1 ENSG00000153147 SMARCA5 H. sapiens SSL Slorth 0.755605 View
ENSG00000070950 RAD18 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.754784 View
ENSG00000064012 CASP8 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.750111 View