LEF1

ENSG00000138795 - H. sapiens

Pathways

Go term Description
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0008134 transcription factor binding
GO:0008301 DNA binding, bending
GO:0030284 estrogen receptor activity
GO:0030331 estrogen receptor binding
GO:0035326 enhancer binding
GO:0042393 histone binding
GO:0042826 histone deacetylase binding
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0045295 gamma-catenin binding
GO:0070016 armadillo repeat domain binding
GO:0070742 C2H2 zinc finger domain binding

Drugs

No drugs in record

Diseases

Disease Name
B-ALL
T-ALL
eyelid sebaceous carcinoma
AML
lymphomas

Orthologs

Gene Organism
pop-1 C. elegans
pan D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000101266 CSNK2A1 ENSG00000138795 LEF1 H. sapiens SDL Slorth 0.987593 View
ENSG00000124762 CDKN1A ENSG00000138795 LEF1 H. sapiens SDL Slorth 0.985743 View
ENSG00000104365 IKBKB ENSG00000138795 LEF1 H. sapiens SDL Slorth 0.98524 View
ENSG00000132155 RAF1 ENSG00000138795 LEF1 H. sapiens SDL Slorth 0.984723 View
ENSG00000005339 CREBBP ENSG00000138795 LEF1 H. sapiens SDL Slorth 0.984715 View
ENSG00000103275 UBE2I ENSG00000138795 LEF1 H. sapiens SDL Slorth 0.984573 View
ENSG00000138795 LEF1 ENSG00000188612 SUMO2 H. sapiens SDL Slorth 0.984541 View
ENSG00000097007 ABL1 ENSG00000138795 LEF1 H. sapiens SDL Slorth 0.983496 View
ENSG00000109971 HSPA8 ENSG00000138795 LEF1 H. sapiens SDL Slorth 0.983041 View
ENSG00000138795 LEF1 ENSG00000170315 UBB H. sapiens SDL Slorth 0.982949 View
ENSG00000138795 LEF1 ENSG00000177606 JUN H. sapiens SDL Slorth 0.981297 View
ENSG00000100030 MAPK1 ENSG00000138795 LEF1 H. sapiens SDL Slorth 0.981114 View
ENSG00000012048 BRCA1 ENSG00000138795 LEF1 H. sapiens SDL Slorth 0.980846 View
ENSG00000123374 CDK2 ENSG00000138795 LEF1 H. sapiens SDL Slorth 0.980147 View
ENSG00000138795 LEF1 ENSG00000139687 RB1 H. sapiens SDL Slorth 0.980049 View
ENSG00000096384 HSP90AB1 ENSG00000138795 LEF1 H. sapiens SDL Slorth 0.979938 View
ENSG00000138795 LEF1 ENSG00000142208 AKT1 H. sapiens SDL Slorth 0.979601 View
ENSG00000116478 HDAC1 ENSG00000138795 LEF1 H. sapiens SDL Slorth 0.979351 View
ENSG00000136997 MYC ENSG00000138795 LEF1 H. sapiens SDL Slorth 0.979184 View
ENSG00000132646 PCNA ENSG00000138795 LEF1 H. sapiens SDL Slorth 0.97907 View
ENSG00000110395 CBL ENSG00000138795 LEF1 H. sapiens SDL Slorth 0.978588 View
ENSG00000113558 SKP1 ENSG00000138795 LEF1 H. sapiens SDL Slorth 0.978532 View
ENSG00000138795 LEF1 ENSG00000150991 UBC H. sapiens SDL Slorth 0.9784 View
ENSG00000091831 ESR1 ENSG00000138795 LEF1 H. sapiens SDL Slorth 0.97838 View
ENSG00000121022 COPS5 ENSG00000138795 LEF1 H. sapiens SDL Slorth 0.977244 View
ENSG00000138795 LEF1 ENSG00000177885 GRB2 H. sapiens SDL Slorth 0.977044 View
ENSG00000109670 FBXW7 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.976617 View
ENSG00000138795 LEF1 ENSG00000141510 TP53 H. sapiens SDL Slorth 0.976242 View
ENSG00000055130 CUL1 ENSG00000138795 LEF1 H. sapiens SDL Slorth 0.976239 View
ENSG00000138795 LEF1 ENSG00000168036 CTNNB1 H. sapiens SDL Slorth 0.976233 View
ENSG00000138795 LEF1 ENSG00000140464 PML H. sapiens SDL Slorth 0.976033 View
ENSG00000138795 LEF1 ENSG00000169083 AR H. sapiens SDL Slorth 0.974365 View
ENSG00000080824 HSP90AA1 ENSG00000138795 LEF1 H. sapiens SDL Slorth 0.973734 View
ENSG00000138795 LEF1 ENSG00000196591 HDAC2 H. sapiens SDL Slorth 0.972519 View
ENSG00000100393 EP300 ENSG00000138795 LEF1 H. sapiens SDL Slorth 0.971891 View
ENSG00000138795 LEF1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.97113 View
ENSG00000133703 KRAS ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.97032 View
ENSG00000138795 LEF1 ENSG00000166949 SMAD3 H. sapiens SDL Slorth 0.969991 View
ENSG00000138795 LEF1 ENSG00000197122 SRC H. sapiens SDL Slorth 0.968074 View
ENSG00000110107 PRPF19 ENSG00000138795 LEF1 H. sapiens SDL Slorth 0.967887 View