PDGFRA

ENSG00000134853 - H. sapiens

Pathways

Go term Description
GO:0004672 protein kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005018 platelet-derived growth factor alpha-receptor activity
GO:0005021 vascular endothelial growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005161 platelet-derived growth factor receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0038085 vascular endothelial growth factor binding
GO:0042803 protein homodimerization activity
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0048407 platelet-derived growth factor binding

Drugs

Drug name Description
BECAPLERMIN Platelet-derived growth factor receptor agonist
LENVATINIB
NINTEDANIB Platelet-derived growth factor receptor inhibitor
PAZOPANIB Tyrosine-protein kinase LCK inhibitor
PONATINIB Tyrosine-protein kinase ABL inhibitor
REGORAFENIB Tyrosine-protein kinase ABL inhibitor
SUNITINIB Macrophage colony stimulating factor receptor inhibitor

Diseases

Disease Name
GIST
idiopathic hypereosinophilic syndrome
paediatric glioblastoma

Orthologs

Gene Organism
Pvr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000134853 PDGFRA ENSG00000144566 RAB5A H. sapiens SSL Slorth 0.763195 View
ENSG00000074319 TSG101 ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.760677 View
ENSG00000134853 PDGFRA ENSG00000172115 CYCS H. sapiens SSL Slorth 0.760177 View
ENSG00000134853 PDGFRA ENSG00000166167 BTRC H. sapiens SSL Slorth 0.759781 View
ENSG00000134853 PDGFRA ENSG00000160294 MCM3AP H. sapiens SSL Slorth 0.759297 View
ENSG00000121481 RNF2 ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.757644 View
ENSG00000114503 NCBP2 ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.756448 View
ENSG00000134853 PDGFRA ENSG00000136810 TXN H. sapiens SSL Slorth 0.754952 View
ENSG00000101557 USP14 ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.754721 View
ENSG00000058729 RIOK2 ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.75196 View
ENSG00000134853 PDGFRA ENSG00000143514 TP53BP2 H. sapiens SSL Slorth 0.751048 View
ENSG00000134853 PDGFRA ENSG00000170142 UBE2E1 H. sapiens SSL Slorth 0.750911 View
ENSG00000134853 PDGFRA ENSG00000197122 SRC H. sapiens SSL Slorth 0.750653 View
ENSG00000104695 PPP2CB ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.750586 View