PDGFRA

ENSG00000134853 - H. sapiens

Pathways

Go term Description
GO:0004672 protein kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005018 platelet-derived growth factor alpha-receptor activity
GO:0005021 vascular endothelial growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005161 platelet-derived growth factor receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0038085 vascular endothelial growth factor binding
GO:0042803 protein homodimerization activity
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0048407 platelet-derived growth factor binding

Drugs

Drug name Description
BECAPLERMIN Platelet-derived growth factor receptor agonist
LENVATINIB
NINTEDANIB Platelet-derived growth factor receptor inhibitor
PAZOPANIB Tyrosine-protein kinase LCK inhibitor
PONATINIB Tyrosine-protein kinase ABL inhibitor
REGORAFENIB Tyrosine-protein kinase ABL inhibitor
SUNITINIB Macrophage colony stimulating factor receptor inhibitor

Diseases

Disease Name
GIST
idiopathic hypereosinophilic syndrome
paediatric glioblastoma

Orthologs

Gene Organism
Pvr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000134853 PDGFRA ENSG00000139343 SNRPF H. sapiens SSL Slorth 0.892333 View
ENSG00000134853 PDGFRA ENSG00000170312 CDK1 H. sapiens SSL Slorth 0.891999 View
ENSG00000112118 MCM3 ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.890523 View
ENSG00000117133 RPF1 ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.890496 View
ENSG00000114767 RRP9 ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.889966 View
ENSG00000110107 PRPF19 ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.889163 View
ENSG00000134853 PDGFRA ENSG00000171824 EXOSC10 H. sapiens SSL Slorth 0.888546 View
ENSG00000134853 PDGFRA ENSG00000187741 FANCA H. sapiens SSL Slorth 0.887829 View
ENSG00000110092 CCND1 ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.887568 View
ENSG00000004897 CDC27 ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.887332 View
ENSG00000134853 PDGFRA ENSG00000166913 YWHAB H. sapiens SSL Slorth 0.887034 View
ENSG00000134853 PDGFRA ENSG00000196591 HDAC2 H. sapiens SSL Slorth 0.886381 View
ENSG00000134853 PDGFRA ENSG00000139842 CUL4A H. sapiens SSL Slorth 0.886329 View
ENSG00000134853 PDGFRA ENSG00000150907 FOXO1 H. sapiens SSL Slorth 0.885975 View
ENSG00000108443 RPS6KB1 ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.885696 View
ENSG00000070010 UFD1L ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.885618 View
ENSG00000062822 POLD1 ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.885092 View
ENSG00000134853 PDGFRA ENSG00000204843 DCTN1 H. sapiens SSL Slorth 0.884834 View
ENSG00000134853 PDGFRA ENSG00000188612 SUMO2 H. sapiens SSL Slorth 0.884643 View
ENSG00000096968 JAK2 ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.884373 View
ENSG00000080815 PSEN1 ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.883806 View
ENSG00000134853 PDGFRA ENSG00000164032 H2AFZ H. sapiens SSL Slorth 0.883253 View
ENSG00000121774 KHDRBS1 ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.883033 View
ENSG00000105810 CDK6 ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.881893 View
ENSG00000102882 MAPK3 ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.881639 View
ENSG00000134853 PDGFRA ENSG00000177084 POLE H. sapiens SSL Slorth 0.881621 View
ENSG00000132341 RAN ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.880733 View
ENSG00000082898 XPO1 ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.880233 View
ENSG00000130939 UBE4B ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.88012 View
ENSG00000134853 PDGFRA ENSG00000187266 EPOR H. sapiens SSL Slorth 0.87944 View
ENSG00000134853 PDGFRA ENSG00000154473 BUB3 H. sapiens SSL Slorth 0.879132 View
ENSG00000113721 PDGFRB ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.879124 View
ENSG00000134308 YWHAQ ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.878695 View
ENSG00000134853 PDGFRA ENSG00000163558 PRKCI H. sapiens SSL Slorth 0.878538 View
ENSG00000134853 PDGFRA ENSG00000166483 WEE1 H. sapiens SSL Slorth 0.878251 View
ENSG00000280548 FBL ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.877418 View
ENSG00000128908 INO80 ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.877141 View
ENSG00000134853 PDGFRA ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.875574 View
ENSG00000123124 WWP1 ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.875448 View
ENSG00000134853 PDGFRA ENSG00000144554 FANCD2 H. sapiens SSL Slorth 0.875167 View