POLE

ENSG00000177084 - H. sapiens

Pathways

Go term Description
GO:0000166 nucleotide binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0008270 zinc ion binding
GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity
GO:0051539 4 iron, 4 sulfur cluster binding

Drugs

Drug name Description
CLOFARABINE DNA inhibitor
CYTARABINE DNA polymerase (alpha/delta/epsilon) inhibitor
FLUDARABINE PHOSPHATE DNA polymerase (alpha/delta/epsilon) inhibitor
GEMCITABINE

Diseases

Disease Name
colorectal carcinoma
endometrioid carcinoma
stomach carcinoma
skin cancer
colorectal cancer susceptibility

Orthologs

Gene Organism
POL2 S. cerevisiae
pole-1 C. elegans
DNApol-epsilon255 D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000112282 MED23 ENSG00000177084 POLE H. sapiens SSL BioGRID 1.0 View
ENSG00000103274 NUBP1 ENSG00000177084 POLE H. sapiens SSL BioGRID 1.0 View
ENSG00000177084 POLE ENSG00000177084 POLE H. sapiens SSL BioGRID 1.0 View
ENSG00000177084 POLE ENSG00000177084 POLE H. sapiens SSL BioGRID 1.0 View
ENSG00000177084 POLE ENSG00000241343 RPL36A H. sapiens SSL BioGRID 1.0 View
ENSG00000177084 POLE ENSG00000111602 TIMELESS H. sapiens SSL BioGRID 1.0 View
ENSG00000136273 HUS1 ENSG00000177084 POLE H. sapiens SSL BioGRID 1.0 View
ENSG00000198862 LTN1 ENSG00000177084 POLE H. sapiens SSL BioGRID 1.0 View
ENSG00000132646 PCNA ENSG00000177084 POLE H. sapiens SDL Slorth 0.993432 View
ENSG00000139687 RB1 ENSG00000177084 POLE H. sapiens SDL Slorth 0.989621 View
ENSG00000012048 BRCA1 ENSG00000177084 POLE H. sapiens SDL Slorth 0.987438 View
ENSG00000166949 SMAD3 ENSG00000177084 POLE H. sapiens SDL Slorth 0.985554 View
ENSG00000150991 UBC ENSG00000177084 POLE H. sapiens SDL Slorth 0.984691 View
ENSG00000123374 CDK2 ENSG00000177084 POLE H. sapiens SDL Slorth 0.984412 View
ENSG00000080824 HSP90AA1 ENSG00000177084 POLE H. sapiens SDL Slorth 0.983913 View
ENSG00000124762 CDKN1A ENSG00000177084 POLE H. sapiens SDL Slorth 0.981915 View
ENSG00000100030 MAPK1 ENSG00000177084 POLE H. sapiens SDL Slorth 0.981244 View
ENSG00000136997 MYC ENSG00000177084 POLE H. sapiens SDL Slorth 0.980681 View
ENSG00000170315 UBB ENSG00000177084 POLE H. sapiens SDL Slorth 0.980485 View
ENSG00000146648 EGFR ENSG00000177084 POLE H. sapiens SDL Slorth 0.980404 View
ENSG00000170312 CDK1 ENSG00000177084 POLE H. sapiens SDL Slorth 0.977825 View
ENSG00000100393 EP300 ENSG00000177084 POLE H. sapiens SDL Slorth 0.977457 View
ENSG00000149273 RPS3 ENSG00000177084 POLE H. sapiens SDL Slorth 0.976708 View
ENSG00000101266 CSNK2A1 ENSG00000177084 POLE H. sapiens SDL Slorth 0.976696 View
ENSG00000141510 TP53 ENSG00000177084 POLE H. sapiens SDL Slorth 0.974997 View
ENSG00000175104 TRAF6 ENSG00000177084 POLE H. sapiens SDL Slorth 0.974962 View
ENSG00000162385 MAGOH ENSG00000177084 POLE H. sapiens SDL Slorth 0.974916 View
ENSG00000142208 AKT1 ENSG00000177084 POLE H. sapiens SDL Slorth 0.974302 View
ENSG00000133703 KRAS ENSG00000177084 POLE H. sapiens SSL Slorth 0.973949 View
ENSG00000005339 CREBBP ENSG00000177084 POLE H. sapiens SDL Slorth 0.97361 View
ENSG00000116478 HDAC1 ENSG00000177084 POLE H. sapiens SDL Slorth 0.973501 View
ENSG00000169375 SIN3A ENSG00000177084 POLE H. sapiens SDL Slorth 0.973419 View
ENSG00000110395 CBL ENSG00000177084 POLE H. sapiens SDL Slorth 0.973087 View
ENSG00000091831 ESR1 ENSG00000177084 POLE H. sapiens SDL Slorth 0.972952 View
ENSG00000109670 FBXW7 ENSG00000177084 POLE H. sapiens SSL Slorth 0.972931 View
ENSG00000168610 STAT3 ENSG00000177084 POLE H. sapiens SDL Slorth 0.970341 View
ENSG00000168036 CTNNB1 ENSG00000177084 POLE H. sapiens SDL Slorth 0.969832 View
ENSG00000169083 AR ENSG00000177084 POLE H. sapiens SDL Slorth 0.969087 View
ENSG00000103275 UBE2I ENSG00000177084 POLE H. sapiens SDL Slorth 0.968897 View
ENSG00000140464 PML ENSG00000177084 POLE H. sapiens SDL Slorth 0.967754 View