SIRT1 - MTA2

SSL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
SIRT1	ENSG00000096717	No diseases in record	No drugs in record	core promoter sequence-specific DNA binding p53 binding transcription corepressor activity histone deacetylase activity protein binding protein C-terminus binding transcription factor binding NAD-dependent histone deacetylase activity deacetylase activity enzyme binding protein deacetylase activity NAD-dependent protein deacetylase activity nuclear hormone receptor binding histone binding identical protein binding HLH domain binding bHLH transcription factor binding metal ion binding NAD-dependent histone deacetylase activity (H3-K9 specific) mitogen-activated protein kinase binding NAD+ binding keratin filament binding NAD+ ADP-ribosyltransferase activity	HST1 (S. cerevisiae) SIR2 (S. cerevisiae) sir-2.1 (C. elegans)
MTA2	ENSG00000149480	No diseases in record	No drugs in record	transcription factor activity, transcription factor binding RNA polymerase II transcription factor binding RNA polymerase II repressing transcription factor binding transcription factor activity, sequence-specific DNA binding histone deacetylase activity protein binding zinc ion binding histone deacetylase binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding nucleosomal DNA binding	lin-40 (C. elegans) MTA1-like (D. melanogaster)