SPEN - SIRT1

SDL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
SPEN	ENSG00000065526	SMZL adenoid cystic carcinoma DLBCL	No drugs in record	nucleotide binding RNA polymerase II transcription factor binding transcriptional repressor activity, RNA polymerase II transcription factor binding nucleic acid binding DNA binding protein binding	spen (D. melanogaster)
SIRT1	ENSG00000096717	No diseases in record	No drugs in record	core promoter sequence-specific DNA binding p53 binding transcription corepressor activity histone deacetylase activity protein binding protein C-terminus binding transcription factor binding NAD-dependent histone deacetylase activity deacetylase activity enzyme binding protein deacetylase activity NAD-dependent protein deacetylase activity nuclear hormone receptor binding histone binding identical protein binding HLH domain binding bHLH transcription factor binding metal ion binding NAD-dependent histone deacetylase activity (H3-K9 specific) mitogen-activated protein kinase binding NAD+ binding keratin filament binding NAD+ ADP-ribosyltransferase activity	HST1 (S. cerevisiae) SIR2 (S. cerevisiae) sir-2.1 (C. elegans)