USP21 - SMAD3

SDL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
USP21	ENSG00000143258	No diseases in record	No drugs in record	transcription coactivator activity thiol-dependent ubiquitin-specific protease activity protein binding cysteine-type peptidase activity NEDD8-specific protease activity metal ion binding	DOA4 (S. cerevisiae) UBP5 (S. cerevisiae)
SMAD3	ENSG00000166949	colorectal carcinoma oral squamous cell carcinoma	No drugs in record	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity, RNA polymerase II core promoter sequence-specific core promoter proximal region sequence-specific DNA binding RNA polymerase II activating transcription factor binding transcription factor activity, sequence-specific DNA binding transforming growth factor beta receptor binding protein binding collagen binding beta-catenin binding transcription factor binding zinc ion binding protein kinase binding phosphatase binding transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity chromatin DNA binding ubiquitin protein ligase binding enhancer binding identical protein binding protein homodimerization activity ubiquitin binding bHLH transcription factor binding sequence-specific DNA binding transcription regulatory region DNA binding protein heterodimerization activity co-SMAD binding R-SMAD binding transcription factor activity, protein binding	sma-3 (C. elegans) sma-2 (C. elegans)