KIT

ENSG00000157404 - H. sapiens

Pathways

Go term Description
GO:0002020 protease binding
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0005020 stem cell factor receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0019955 cytokine binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity

Drugs

Drug name Description
CABOZANTINIB
DASATINIB Tyrosine-protein kinase ABL inhibitor
IMATINIB Tyrosine-protein kinase ABL inhibitor
LENVATINIB
PAZOPANIB Tyrosine-protein kinase LCK inhibitor
PONATINIB Tyrosine-protein kinase ABL inhibitor
REGORAFENIB Tyrosine-protein kinase ABL inhibitor
SORAFENIB Serine/threonine-protein kinase RAF inhibitor
SUNITINIB Macrophage colony stimulating factor receptor inhibitor

Diseases

Disease Name
GIST
AML
TGCT
mastocytosis
mucosal melanoma
epithelioma

Orthologs

Gene Organism
Pvr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000143799 PARP1 ENSG00000157404 KIT H. sapiens SSL Slorth 0.818459 View
ENSG00000108840 HDAC5 ENSG00000157404 KIT H. sapiens SSL Slorth 0.818164 View
ENSG00000050748 MAPK9 ENSG00000157404 KIT H. sapiens SSL Slorth 0.818027 View
ENSG00000114166 KAT2B ENSG00000157404 KIT H. sapiens SSL Slorth 0.817259 View
ENSG00000150459 SAP18 ENSG00000157404 KIT H. sapiens SSL Slorth 0.817212 View
ENSG00000096384 HSP90AB1 ENSG00000157404 KIT H. sapiens SSL Slorth 0.817087 View
ENSG00000157404 KIT ENSG00000167513 CDT1 H. sapiens SSL Slorth 0.816381 View
ENSG00000145375 SPATA5 ENSG00000157404 KIT H. sapiens SSL Slorth 0.815926 View
ENSG00000153250 RBMS1 ENSG00000157404 KIT H. sapiens SSL Slorth 0.815847 View
ENSG00000145604 SKP2 ENSG00000157404 KIT H. sapiens SSL Slorth 0.815706 View
ENSG00000114573 ATP6V1A ENSG00000157404 KIT H. sapiens SSL Slorth 0.815403 View
ENSG00000157404 KIT ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.815294 View
ENSG00000130699 TAF4 ENSG00000157404 KIT H. sapiens SSL Slorth 0.815165 View
ENSG00000136152 COG3 ENSG00000157404 KIT H. sapiens SSL Slorth 0.814869 View
ENSG00000122512 PMS2 ENSG00000157404 KIT H. sapiens SSL Slorth 0.814093 View
ENSG00000141552 ANAPC11 ENSG00000157404 KIT H. sapiens SSL Slorth 0.81401 View
ENSG00000099940 SNAP29 ENSG00000157404 KIT H. sapiens SSL Slorth 0.813954 View
ENSG00000111276 CDKN1B ENSG00000157404 KIT H. sapiens SSL Slorth 0.813737 View
ENSG00000100142 POLR2F ENSG00000157404 KIT H. sapiens SSL Slorth 0.813592 View
ENSG00000126458 RRAS ENSG00000157404 KIT H. sapiens SSL Slorth 0.812559 View
ENSG00000042088 TDP1 ENSG00000157404 KIT H. sapiens SSL Slorth 0.812556 View
ENSG00000053372 MRTO4 ENSG00000157404 KIT H. sapiens SSL Slorth 0.812257 View
ENSG00000116141 MARK1 ENSG00000157404 KIT H. sapiens SSL Slorth 0.811463 View
ENSG00000105329 TGFB1 ENSG00000157404 KIT H. sapiens SSL Slorth 0.810608 View
ENSG00000118503 TNFAIP3 ENSG00000157404 KIT H. sapiens SSL Slorth 0.808374 View
ENSG00000157404 KIT ENSG00000181163 NPM1 H. sapiens SSL Slorth 0.808075 View
ENSG00000128052 KDR ENSG00000157404 KIT H. sapiens SSL Slorth 0.807912 View
ENSG00000131759 RARA ENSG00000157404 KIT H. sapiens SSL Slorth 0.807839 View
ENSG00000157404 KIT ENSG00000159461 AMFR H. sapiens SSL Slorth 0.807771 View
ENSG00000126934 MAP2K2 ENSG00000157404 KIT H. sapiens SSL Slorth 0.806511 View
ENSG00000113263 ITK ENSG00000157404 KIT H. sapiens SSL Slorth 0.805885 View
ENSG00000135250 SRPK2 ENSG00000157404 KIT H. sapiens SSL Slorth 0.805874 View
ENSG00000103194 USP10 ENSG00000157404 KIT H. sapiens SSL Slorth 0.805467 View
ENSG00000074266 EED ENSG00000157404 KIT H. sapiens SSL Slorth 0.805431 View
ENSG00000076555 ACACB ENSG00000157404 KIT H. sapiens SSL Slorth 0.805214 View
ENSG00000100387 RBX1 ENSG00000157404 KIT H. sapiens SSL Slorth 0.804923 View
ENSG00000157404 KIT ENSG00000183684 ALYREF H. sapiens SSL Slorth 0.804552 View
ENSG00000157404 KIT ENSG00000196419 XRCC6 H. sapiens SSL Slorth 0.804109 View
ENSG00000136279 DBNL ENSG00000157404 KIT H. sapiens SSL Slorth 0.804099 View
ENSG00000157404 KIT ENSG00000183765 CHEK2 H. sapiens SSL Slorth 0.803603 View