TOP2A

ENSG00000131747 - H. sapiens

Pathways

Go term Description
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0008094 DNA-dependent ATPase activity
GO:0008144 drug binding
GO:0008301 DNA binding, bending
GO:0019899 enzyme binding
GO:0042803 protein homodimerization activity
GO:0042826 histone deacetylase binding
GO:0043130 ubiquitin binding
GO:0046982 protein heterodimerization activity

Drugs

Drug name Description
DAUNORUBICIN DNA topoisomerase II alpha inhibitor
DOXORUBICIN DNA topoisomerase II alpha inhibitor
EPIRUBICIN
ETOPOSIDE DNA topoisomerase II inhibitor
ETOPOSIDE PHOSPHATE DNA topoisomerase II alpha inhibitor
IDARUBICIN DNA topoisomerase II alpha inhibitor
MITOXANTRONE
PODOFILOX
TENIPOSIDE DNA topoisomerase II inhibitor
VALRUBICIN DNA topoisomerase II alpha inhibitor

Diseases

No diseases in record

Orthologs

Gene Organism
TOP2 S. cerevisiae
cin-4 C. elegans
top-2 C. elegans

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000131747 TOP2A ENSG00000134686 PHC2 H. sapiens SDL Slorth 0.907248 View
ENSG00000131747 TOP2A ENSG00000170144 HNRNPA3 H. sapiens SSL Slorth 0.9072 View
ENSG00000131747 TOP2A ENSG00000172845 SP3 H. sapiens SDL Slorth 0.907167 View
ENSG00000131747 TOP2A ENSG00000169139 UBE2V2 H. sapiens SDL Slorth 0.907138 View
ENSG00000131747 TOP2A ENSG00000159216 RUNX1 H. sapiens SDL Slorth 0.90701 View
ENSG00000131747 TOP2A ENSG00000245848 CEBPA H. sapiens SDL Slorth 0.906883 View
ENSG00000131747 TOP2A ENSG00000182255 KCNA4 H. sapiens SDL Slorth 0.906835 View
ENSG00000130382 MLLT1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.906818 View
ENSG00000131747 TOP2A ENSG00000197275 RAD54B H. sapiens SDL Slorth 0.906748 View
ENSG00000131747 TOP2A ENSG00000132383 RPA1 H. sapiens SDL Slorth 0.906743 View
ENSG00000131747 TOP2A ENSG00000149273 RPS3 H. sapiens SDL Slorth 0.906716 View
ENSG00000065427 KARS ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.906628 View
ENSG00000131747 TOP2A ENSG00000153561 RMND5A H. sapiens SDL Slorth 0.906564 View
ENSG00000131747 TOP2A ENSG00000142208 AKT1 H. sapiens SSL Slorth 0.906402 View
ENSG00000131747 TOP2A ENSG00000185591 SP1 H. sapiens SSL Slorth 0.906305 View
ENSG00000131747 TOP2A ENSG00000196911 KPNA5 H. sapiens SDL Slorth 0.906252 View
ENSG00000131747 TOP2A ENSG00000268173 AC007192.4 H. sapiens SDL Slorth 0.906196 View
ENSG00000116288 PARK7 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.905887 View
ENSG00000131747 TOP2A ENSG00000159461 AMFR H. sapiens SSL Slorth 0.905881 View
ENSG00000131747 TOP2A ENSG00000198807 PAX9 H. sapiens SDL Slorth 0.905836 View
ENSG00000131747 TOP2A ENSG00000134574 DDB2 H. sapiens SSL Slorth 0.905832 View
ENSG00000079102 RUNX1T1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.905726 View
ENSG00000131747 TOP2A ENSG00000171223 JUNB H. sapiens SSL Slorth 0.905638 View
ENSG00000131747 TOP2A ENSG00000132341 RAN H. sapiens SDL Slorth 0.905377 View
ENSG00000131747 TOP2A ENSG00000173473 SMARCC1 H. sapiens SDL Slorth 0.90523 View
ENSG00000131747 TOP2A ENSG00000137815 RTF1 H. sapiens SDL Slorth 0.905175 View
ENSG00000131747 TOP2A ENSG00000163743 RCHY1 H. sapiens SSL Slorth 0.904948 View
ENSG00000131747 TOP2A ENSG00000139352 ASCL1 H. sapiens SDL Slorth 0.904835 View
ENSG00000049759 NEDD4L ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.90483 View
ENSG00000131747 TOP2A ENSG00000132155 RAF1 H. sapiens SSL Slorth 0.904664 View
ENSG00000115524 SF3B1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.904557 View
ENSG00000131747 TOP2A ENSG00000166197 NOLC1 H. sapiens SSL Slorth 0.90455 View
ENSG00000131747 TOP2A ENSG00000183741 CBX6 H. sapiens SDL Slorth 0.90444 View
ENSG00000122512 PMS2 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.904335 View
ENSG00000131747 TOP2A ENSG00000179262 RAD23A H. sapiens SSL Slorth 0.904333 View
ENSG00000087586 AURKA ENSG00000131747 TOP2A H. sapiens SDL Slorth 0.904283 View
ENSG00000131747 TOP2A ENSG00000169398 PTK2 H. sapiens SSL Slorth 0.904103 View
ENSG00000131747 TOP2A ENSG00000166192 SENP8 H. sapiens SDL Slorth 0.904095 View
ENSG00000100906 NFKBIA ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.903633 View
ENSG00000131747 TOP2A ENSG00000139797 RNF113B H. sapiens SDL Slorth 0.903574 View