TOP2A

ENSG00000131747 - H. sapiens

Pathways

Go term Description
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0008094 DNA-dependent ATPase activity
GO:0008144 drug binding
GO:0008301 DNA binding, bending
GO:0019899 enzyme binding
GO:0042803 protein homodimerization activity
GO:0042826 histone deacetylase binding
GO:0043130 ubiquitin binding
GO:0046982 protein heterodimerization activity

Drugs

Drug name Description
DAUNORUBICIN DNA topoisomerase II alpha inhibitor
DOXORUBICIN DNA topoisomerase II alpha inhibitor
EPIRUBICIN
ETOPOSIDE DNA topoisomerase II inhibitor
ETOPOSIDE PHOSPHATE DNA topoisomerase II alpha inhibitor
IDARUBICIN DNA topoisomerase II alpha inhibitor
MITOXANTRONE
PODOFILOX
TENIPOSIDE DNA topoisomerase II inhibitor
VALRUBICIN DNA topoisomerase II alpha inhibitor

Diseases

No diseases in record

Orthologs

Gene Organism
TOP2 S. cerevisiae
cin-4 C. elegans
top-2 C. elegans

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000131747 TOP2A ENSG00000197063 MAFG H. sapiens SDL Slorth 0.923034 View
ENSG00000131747 TOP2A ENSG00000185896 LAMP1 H. sapiens SDL Slorth 0.922936 View
ENSG00000106299 WASL ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.922836 View
ENSG00000131747 TOP2A ENSG00000173039 RELA H. sapiens SSL Slorth 0.92264 View
ENSG00000078747 ITCH ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.922572 View
ENSG00000129559 NEDD8 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.922432 View
ENSG00000131747 TOP2A ENSG00000171791 BCL2 H. sapiens SSL Slorth 0.922117 View
ENSG00000131747 TOP2A ENSG00000146872 TLK2 H. sapiens SDL Slorth 0.922021 View
ENSG00000131747 TOP2A ENSG00000149554 CHEK1 H. sapiens SDL Slorth 0.921677 View
ENSG00000131747 TOP2A ENSG00000253729 PRKDC H. sapiens SDL Slorth 0.921614 View
ENSG00000131747 TOP2A ENSG00000254087 LYN H. sapiens SSL Slorth 0.921596 View
ENSG00000131747 TOP2A ENSG00000133316 WDR74 H. sapiens SSL Slorth 0.921519 View
ENSG00000107643 MAPK8 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.921496 View
ENSG00000131747 TOP2A ENSG00000141543 EIF4A3 H. sapiens SSL Slorth 0.921492 View
ENSG00000131747 TOP2A ENSG00000139687 RB1 H. sapiens SSL Slorth 0.921438 View
ENSG00000131747 TOP2A ENSG00000166949 SMAD3 H. sapiens SSL Slorth 0.921419 View
ENSG00000131747 TOP2A ENSG00000153147 SMARCA5 H. sapiens SSL Slorth 0.921313 View
ENSG00000104365 IKBKB ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.921299 View
ENSG00000131747 TOP2A ENSG00000163938 GNL3 H. sapiens SSL Slorth 0.921125 View
ENSG00000116459 ATP5F1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.921103 View
ENSG00000131747 TOP2A ENSG00000146094 DOK3 H. sapiens SDL Slorth 0.921077 View
ENSG00000131747 TOP2A ENSG00000240771 ARHGEF25 H. sapiens SDL Slorth 0.920882 View
ENSG00000131747 TOP2A ENSG00000131941 RHPN2 H. sapiens SDL Slorth 0.920882 View
ENSG00000131747 TOP2A ENSG00000138395 CDK15 H. sapiens SDL Slorth 0.920871 View
ENSG00000002016 RAD52 ENSG00000131747 TOP2A H. sapiens SDL Slorth 0.920804 View
ENSG00000082701 GSK3B ENSG00000131747 TOP2A H. sapiens SDL Slorth 0.920635 View
ENSG00000112062 MAPK14 ENSG00000131747 TOP2A H. sapiens SDL Slorth 0.920115 View
ENSG00000101161 PRPF6 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.920002 View
ENSG00000131747 TOP2A ENSG00000175197 DDIT3 H. sapiens SSL Slorth 0.919886 View
ENSG00000131747 TOP2A ENSG00000165806 CASP7 H. sapiens SSL Slorth 0.919784 View
ENSG00000131747 TOP2A ENSG00000165119 HNRNPK H. sapiens SDL Slorth 0.91977 View
ENSG00000131747 TOP2A ENSG00000138613 APH1B H. sapiens SDL Slorth 0.919616 View
ENSG00000131747 TOP2A ENSG00000134987 WDR36 H. sapiens SSL Slorth 0.919275 View
ENSG00000131747 TOP2A ENSG00000175766 EIF4E1B H. sapiens SDL Slorth 0.919268 View
ENSG00000131747 TOP2A ENSG00000154237 LRRK1 H. sapiens SDL Slorth 0.919225 View
ENSG00000131747 TOP2A ENSG00000185811 IKZF1 H. sapiens SDL Slorth 0.919103 View
ENSG00000131747 TOP2A ENSG00000196218 RYR1 H. sapiens SDL Slorth 0.918944 View
ENSG00000010017 RANBP9 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.918915 View
ENSG00000103126 AXIN1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.918914 View
ENSG00000131747 TOP2A ENSG00000183765 CHEK2 H. sapiens SSL Slorth 0.91885 View