SIR2 - POL2

SDL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
SIR2	YDL042C	No diseases in record	No drugs in record	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides NAD-dependent histone deacetylase activity NAD-dependent histone deacetylase activity (H3-K14 specific) hydrolase activity nucleosome binding zinc ion binding NAD binding NAD+ binding metal ion binding NAD-dependent histone deacetylase activity (H3-K9 specific) NAD-dependent histone deacetylase activity (H4-K16 specific) histone deacetylase activity (H3-K4 specific) histone deacetylase activity (H3-K9 specific) histone deacetylase activity histone deacetylase activity (H4-K16 specific) histone deacetylase activity (H3-K14 specific)	SIRT1 (H. sapiens)
POL2	YNL262W	No diseases in record	No drugs in record	mRNA binding DNA binding DNA-directed DNA polymerase activity 3'-5' exonuclease activity metal ion binding double-stranded DNA binding 4 iron, 4 sulfur cluster binding transferase activity nucleotidyltransferase activity nucleotide binding nucleic acid binding zinc ion binding iron-sulfur cluster binding single-stranded DNA binding single-stranded DNA 3'-5' exodeoxyribonuclease activity	POLE (H. sapiens)