ERBB2

ENSG00000141736 - H. sapiens

Pathways

Go term Description
GO:0001042 RNA polymerase I core binding
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0019903 protein phosphatase binding
GO:0042802 identical protein binding
GO:0043125 ErbB-3 class receptor binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
GO:0019838 growth factor binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PERTUZUMAB Receptor protein-tyrosine kinase erbB-2 inhibitor
TRASTUZUMAB Receptor protein-tyrosine kinase erbB-2 inhibitor
TRASTUZUMAB EMTANSINE Tubulin inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
breast
ovarian
other tumour types
NSCLC
gastric

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000141736 ERBB2 ENSG00000169813 HNRNPF H. sapiens SSL Slorth 0.976832 View
ENSG00000141736 ERBB2 ENSG00000183207 RUVBL2 H. sapiens SSL Slorth 0.976745 View
ENSG00000082701 GSK3B ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.976736 View
ENSG00000141736 ERBB2 ENSG00000170004 CHD3 H. sapiens SSL Slorth 0.976703 View
ENSG00000141736 ERBB2 ENSG00000150907 FOXO1 H. sapiens SSL Slorth 0.976634 View
ENSG00000133703 KRAS ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.976539 View
ENSG00000096717 SIRT1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.976318 View
ENSG00000141736 ERBB2 ENSG00000169045 HNRNPH1 H. sapiens SSL Slorth 0.976244 View
ENSG00000141736 ERBB2 ENSG00000244687 UBE2V1 H. sapiens SSL Slorth 0.976161 View
ENSG00000135486 HNRNPA1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.976026 View
ENSG00000012048 BRCA1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.975949 View
ENSG00000112062 MAPK14 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.975933 View
ENSG00000113575 PPP2CA ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.975713 View
ENSG00000141736 ERBB2 ENSG00000183735 TBK1 H. sapiens SSL Slorth 0.975556 View
ENSG00000141736 ERBB2 ENSG00000168283 BMI1 H. sapiens SSL Slorth 0.975549 View
ENSG00000141736 ERBB2 ENSG00000181163 NPM1 H. sapiens SSL Slorth 0.975409 View
ENSG00000141736 ERBB2 ENSG00000157601 MX1 H. sapiens SDL Slorth 0.975321 View
ENSG00000141736 ERBB2 ENSG00000157106 SMG1 H. sapiens SSL Slorth 0.975252 View
ENSG00000141736 ERBB2 ENSG00000163932 PRKCD H. sapiens SSL Slorth 0.975248 View
ENSG00000141736 ERBB2 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.975229 View
ENSG00000141736 ERBB2 ENSG00000156970 BUB1B H. sapiens SSL Slorth 0.975197 View
ENSG00000101966 XIAP ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.975194 View
ENSG00000010810 FYN ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.975064 View
ENSG00000132646 PCNA ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.974977 View
ENSG00000141736 ERBB2 ENSG00000169714 CNBP H. sapiens SDL Slorth 0.974793 View
ENSG00000141736 ERBB2 ENSG00000256223 ZNF10 H. sapiens SDL Slorth 0.974745 View
ENSG00000141736 ERBB2 ENSG00000149930 TAOK2 H. sapiens SDL Slorth 0.974665 View
ENSG00000141736 ERBB2 ENSG00000196591 HDAC2 H. sapiens SSL Slorth 0.974582 View
ENSG00000097007 ABL1 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.974552 View
ENSG00000112592 TBP ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.974348 View
ENSG00000141736 ERBB2 ENSG00000167986 DDB1 H. sapiens SSL Slorth 0.974249 View
ENSG00000141736 ERBB2 ENSG00000188906 LRRK2 H. sapiens SSL Slorth 0.974226 View
ENSG00000111276 CDKN1B ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.974215 View
ENSG00000141736 ERBB2 ENSG00000175793 SFN H. sapiens SSL Slorth 0.974104 View
ENSG00000137693 YAP1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.973918 View
ENSG00000141736 ERBB2 ENSG00000170365 SMAD1 H. sapiens SSL Slorth 0.973886 View
ENSG00000141736 ERBB2 ENSG00000189067 LITAF H. sapiens SDL Slorth 0.973796 View
ENSG00000141736 ERBB2 ENSG00000198742 SMURF1 H. sapiens SSL Slorth 0.973629 View
ENSG00000135341 MAP3K7 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.97355 View
ENSG00000141736 ERBB2 ENSG00000167085 PHB H. sapiens SSL Slorth 0.97355 View