ERBB2

ENSG00000141736 - H. sapiens

Pathways

Go term Description
GO:0001042 RNA polymerase I core binding
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0019903 protein phosphatase binding
GO:0042802 identical protein binding
GO:0043125 ErbB-3 class receptor binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
GO:0019838 growth factor binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PERTUZUMAB Receptor protein-tyrosine kinase erbB-2 inhibitor
TRASTUZUMAB Receptor protein-tyrosine kinase erbB-2 inhibitor
TRASTUZUMAB EMTANSINE Tubulin inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
breast
ovarian
other tumour types
NSCLC
gastric

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000141736 ERBB2 ENSG00000166407 LMO1 H. sapiens SSL Slorth 0.752104 View
ENSG00000109118 PHF12 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.751924 View
ENSG00000141736 ERBB2 ENSG00000175324 LSM1 H. sapiens SSL Slorth 0.751799 View
ENSG00000141736 ERBB2 ENSG00000196367 TRRAP H. sapiens SSL Slorth 0.751637 View
ENSG00000086589 RBM22 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.750914 View
ENSG00000120705 ETF1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.750627 View
ENSG00000124216 SNAI1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.750534 View
ENSG00000141736 ERBB2 ENSG00000185920 PTCH1 H. sapiens SSL Slorth 0.750311 View
ENSG00000122545 SEPT7 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.75019 View