ERBB2

ENSG00000141736 - H. sapiens

Pathways

Go term Description
GO:0001042 RNA polymerase I core binding
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0019903 protein phosphatase binding
GO:0042802 identical protein binding
GO:0043125 ErbB-3 class receptor binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
GO:0019838 growth factor binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PERTUZUMAB Receptor protein-tyrosine kinase erbB-2 inhibitor
TRASTUZUMAB Receptor protein-tyrosine kinase erbB-2 inhibitor
TRASTUZUMAB EMTANSINE Tubulin inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
breast
ovarian
other tumour types
NSCLC
gastric

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000101003 GINS1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.813712 View
ENSG00000111596 CNOT2 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.813597 View
ENSG00000101557 USP14 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.81351 View
ENSG00000141736 ERBB2 ENSG00000174738 NR1D2 H. sapiens SSL Slorth 0.812725 View
ENSG00000088833 NSFL1C ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.812724 View
ENSG00000141736 ERBB2 ENSG00000149100 EIF3M H. sapiens SSL Slorth 0.812646 View
ENSG00000141736 ERBB2 ENSG00000186350 RXRA H. sapiens SSL Slorth 0.812563 View
ENSG00000105968 H2AFV ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.812268 View
ENSG00000141736 ERBB2 ENSG00000214102 WEE2 H. sapiens SSL Slorth 0.812241 View
ENSG00000066027 PPP2R5A ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.812223 View
ENSG00000141552 ANAPC11 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.812197 View
ENSG00000141736 ERBB2 ENSG00000175662 TOM1L2 H. sapiens SSL Slorth 0.812027 View
ENSG00000100401 RANGAP1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.811923 View
ENSG00000141736 ERBB2 ENSG00000184110 EIF3C H. sapiens SSL Slorth 0.811685 View
ENSG00000122958 VPS26A ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.81165 View
ENSG00000020922 MRE11 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.811319 View
ENSG00000134899 ERCC5 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.811148 View
ENSG00000119912 IDE ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.810591 View
ENSG00000133706 LARS ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.810362 View
ENSG00000141736 ERBB2 ENSG00000160087 UBE2J2 H. sapiens SSL Slorth 0.809976 View
ENSG00000141736 ERBB2 ENSG00000189079 ARID2 H. sapiens SSL Slorth 0.809805 View
ENSG00000141736 ERBB2 ENSG00000155508 CNOT8 H. sapiens SSL Slorth 0.809315 View
ENSG00000118058 KMT2A ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.808368 View
ENSG00000105329 TGFB1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.808135 View
ENSG00000141736 ERBB2 ENSG00000168092 PAFAH1B2 H. sapiens SSL Slorth 0.808089 View
ENSG00000141736 ERBB2 ENSG00000171435 KSR2 H. sapiens SSL Slorth 0.807651 View
ENSG00000141736 ERBB2 ENSG00000143851 PTPN7 H. sapiens SSL Slorth 0.807584 View
ENSG00000070018 LRP6 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.807534 View
ENSG00000141736 ERBB2 ENSG00000266173 STRADA H. sapiens SSL Slorth 0.807369 View
ENSG00000141736 ERBB2 ENSG00000165506 DNAAF2 H. sapiens SSL Slorth 0.80689 View
ENSG00000141736 ERBB2 ENSG00000176601 MAP3K19 H. sapiens SSL Slorth 0.80689 View
ENSG00000141736 ERBB2 ENSG00000176248 ANAPC2 H. sapiens SSL Slorth 0.806735 View
ENSG00000141736 ERBB2 ENSG00000148660 CAMK2G H. sapiens SSL Slorth 0.806409 View
ENSG00000034713 GABARAPL2 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.806283 View
ENSG00000135476 ESPL1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.806197 View
ENSG00000141736 ERBB2 ENSG00000148484 RSU1 H. sapiens SSL Slorth 0.806068 View
ENSG00000104885 DOT1L ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.80597 View
ENSG00000089053 ANAPC5 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.805069 View
ENSG00000141736 ERBB2 ENSG00000196262 PPIA H. sapiens SSL Slorth 0.804926 View
ENSG00000132196 HSD17B7 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.804896 View