ERBB2

ENSG00000141736 - H. sapiens

Pathways

Go term Description
GO:0001042 RNA polymerase I core binding
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0019903 protein phosphatase binding
GO:0042802 identical protein binding
GO:0043125 ErbB-3 class receptor binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
GO:0019838 growth factor binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PERTUZUMAB Receptor protein-tyrosine kinase erbB-2 inhibitor
TRASTUZUMAB Receptor protein-tyrosine kinase erbB-2 inhibitor
TRASTUZUMAB EMTANSINE Tubulin inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
breast
ovarian
other tumour types
NSCLC
gastric

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000054118 THRAP3 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.758981 View
ENSG00000079805 DNM2 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.758753 View
ENSG00000141736 ERBB2 ENSG00000213465 ARL2 H. sapiens SSL Slorth 0.758637 View
ENSG00000141736 ERBB2 ENSG00000179091 CYC1 H. sapiens SSL Slorth 0.758632 View
ENSG00000020633 RUNX3 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.758458 View
ENSG00000017797 RALBP1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.758371 View
ENSG00000141736 ERBB2 ENSG00000163527 STT3B H. sapiens SSL Slorth 0.7583 View
ENSG00000141736 ERBB2 ENSG00000179632 MAF1 H. sapiens SSL Slorth 0.758273 View
ENSG00000141736 ERBB2 ENSG00000175643 RMI2 H. sapiens SSL Slorth 0.758214 View
ENSG00000112249 ASCC3 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.758171 View
ENSG00000141736 ERBB2 ENSG00000171148 TADA3 H. sapiens SSL Slorth 0.757533 View
ENSG00000141736 ERBB2 ENSG00000142733 MAP3K6 H. sapiens SSL Slorth 0.757512 View
ENSG00000126458 RRAS ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.757037 View
ENSG00000136930 PSMB7 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.756882 View
ENSG00000135766 EGLN1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.756798 View
ENSG00000140682 TGFB1I1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.756685 View
ENSG00000141736 ERBB2 ENSG00000241878 PISD H. sapiens SSL Slorth 0.756407 View
ENSG00000141736 ERBB2 ENSG00000204217 BMPR2 H. sapiens SSL Slorth 0.756366 View
ENSG00000141736 ERBB2 ENSG00000177283 FZD8 H. sapiens SSL Slorth 0.756275 View
ENSG00000107201 DDX58 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.755795 View
ENSG00000105401 CDC37 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.755654 View
ENSG00000141736 ERBB2 ENSG00000153071 DAB2 H. sapiens SSL Slorth 0.755569 View
ENSG00000137054 POLR1E ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.755468 View
ENSG00000086061 DNAJA1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.755162 View
ENSG00000141736 ERBB2 ENSG00000157020 SEC13 H. sapiens SSL Slorth 0.755129 View
ENSG00000128578 STRIP2 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.754988 View
ENSG00000141736 ERBB2 ENSG00000169679 BUB1 H. sapiens SSL Slorth 0.754376 View
ENSG00000100813 ACIN1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.754264 View
ENSG00000141736 ERBB2 ENSG00000211455 STK38L H. sapiens SSL Slorth 0.753984 View
ENSG00000141736 ERBB2 ENSG00000163541 SUCLG1 H. sapiens SSL Slorth 0.753689 View
ENSG00000141736 ERBB2 ENSG00000148229 POLE3 H. sapiens SSL Slorth 0.753681 View
ENSG00000100554 ATP6V1D ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.753387 View
ENSG00000141736 ERBB2 ENSG00000247077 PGAM5 H. sapiens SSL Slorth 0.753384 View
ENSG00000083799 CYLD ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.753249 View
ENSG00000137267 TUBB2A ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.753106 View
ENSG00000023228 NDUFS1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.753062 View
ENSG00000141736 ERBB2 ENSG00000170485 NPAS2 H. sapiens SSL Slorth 0.752971 View
ENSG00000122691 TWIST1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.752812 View
ENSG00000141736 ERBB2 ENSG00000155363 MOV10 H. sapiens SSL Slorth 0.752546 View
ENSG00000141736 ERBB2 ENSG00000255150 EID3 H. sapiens SSL Slorth 0.752224 View