ERBB2

ENSG00000141736 - H. sapiens

Pathways

Go term Description
GO:0001042 RNA polymerase I core binding
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0019903 protein phosphatase binding
GO:0042802 identical protein binding
GO:0043125 ErbB-3 class receptor binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
GO:0019838 growth factor binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PERTUZUMAB Receptor protein-tyrosine kinase erbB-2 inhibitor
TRASTUZUMAB Receptor protein-tyrosine kinase erbB-2 inhibitor
TRASTUZUMAB EMTANSINE Tubulin inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
breast
ovarian
other tumour types
NSCLC
gastric

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000126581 BECN1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.875352 View
ENSG00000111859 NEDD9 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.875258 View
ENSG00000096063 SRPK1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.875121 View
ENSG00000141736 ERBB2 ENSG00000205339 IPO7 H. sapiens SSL Slorth 0.874848 View
ENSG00000141736 ERBB2 ENSG00000166797 FAM96A H. sapiens SSL Slorth 0.874846 View
ENSG00000141736 ERBB2 ENSG00000179776 CDH5 H. sapiens SSL Slorth 0.874794 View
ENSG00000112640 PPP2R5D ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.874791 View
ENSG00000138668 HNRNPD ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.87462 View
ENSG00000100297 MCM5 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.874579 View
ENSG00000141736 ERBB2 ENSG00000145242 EPHA5 H. sapiens SSL Slorth 0.874457 View
ENSG00000141736 ERBB2 ENSG00000220205 VAMP2 H. sapiens SSL Slorth 0.874384 View
ENSG00000108055 SMC3 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.874264 View
ENSG00000068078 FGFR3 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.873888 View
ENSG00000141736 ERBB2 ENSG00000155097 ATP6V1C1 H. sapiens SSL Slorth 0.873723 View
ENSG00000141736 ERBB2 ENSG00000173020 GRK2 H. sapiens SSL Slorth 0.873666 View
ENSG00000141736 ERBB2 ENSG00000182247 UBE2E2 H. sapiens SSL Slorth 0.873503 View
ENSG00000141736 ERBB2 ENSG00000204388 HSPA1B H. sapiens SSL Slorth 0.873326 View
ENSG00000141736 ERBB2 ENSG00000167216 KATNAL2 H. sapiens SSL Slorth 0.873293 View
ENSG00000141736 ERBB2 ENSG00000166233 ARIH1 H. sapiens SSL Slorth 0.873154 View
ENSG00000137413 TAF8 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.873079 View
ENSG00000141736 ERBB2 ENSG00000145349 CAMK2D H. sapiens SSL Slorth 0.872991 View
ENSG00000141736 ERBB2 ENSG00000198700 IPO9 H. sapiens SSL Slorth 0.872891 View
ENSG00000122566 HNRNPA2B1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.872808 View
ENSG00000141736 ERBB2 ENSG00000148516 ZEB1 H. sapiens SSL Slorth 0.8727 View
ENSG00000115085 ZAP70 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.872652 View
ENSG00000141736 ERBB2 ENSG00000170776 AKAP13 H. sapiens SSL Slorth 0.872443 View
ENSG00000141736 ERBB2 ENSG00000184967 NOC4L H. sapiens SSL Slorth 0.872273 View
ENSG00000141736 ERBB2 ENSG00000172115 CYCS H. sapiens SSL Slorth 0.872213 View
ENSG00000047932 GOPC ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.872194 View
ENSG00000141736 ERBB2 ENSG00000198952 SMG5 H. sapiens SSL Slorth 0.871916 View
ENSG00000109062 SLC9A3R1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.871626 View
ENSG00000141736 ERBB2 ENSG00000188191 PRKAR1B H. sapiens SSL Slorth 0.871508 View
ENSG00000134440 NARS ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.871493 View
ENSG00000141736 ERBB2 ENSG00000173402 DAG1 H. sapiens SSL Slorth 0.871263 View
ENSG00000141736 ERBB2 ENSG00000152137 HSPB8 H. sapiens SSL Slorth 0.871148 View
ENSG00000123737 EXOSC9 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.871041 View
ENSG00000101161 PRPF6 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.870923 View
ENSG00000141736 ERBB2 ENSG00000166266 CUL5 H. sapiens SSL Slorth 0.870859 View
ENSG00000141736 ERBB2 ENSG00000171720 HDAC3 H. sapiens SSL Slorth 0.87084 View
ENSG00000101109 STK4 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.870577 View