BRAF

ENSG00000157764 - H. sapiens

Pathways

Go term Description
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004709 MAP kinase kinase kinase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0031434 mitogen-activated protein kinase kinase binding
GO:0042802 identical protein binding
GO:0046982 protein heterodimerization activity
GO:0031267 small GTPase binding

Drugs

Drug name Description
DABRAFENIB Serine/threonine-protein kinase B-raf inhibitor
REGORAFENIB Tyrosine-protein kinase ABL inhibitor
SORAFENIB Serine/threonine-protein kinase RAF inhibitor
VEMURAFENIB Serine/threonine-protein kinase B-raf inhibitor

Diseases

Disease Name
melanoma
colorectal
papillary thyroid
borderline ovarian
NSCLC
cholangiocarcinoma
pilocytic astrocytoma
Spitzoid tumour
pancreas acinar carcinoma
melanocytic nevus
prostate
gastric

Orthologs

Gene Organism
lin-45 C. elegans

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000157764 BRAF ENSG00000169750 RAC3 H. sapiens SSL Slorth 0.964687 View
ENSG00000096384 HSP90AB1 ENSG00000157764 BRAF H. sapiens SDL Slorth 0.964651 View
ENSG00000140464 PML ENSG00000157764 BRAF H. sapiens SSL Slorth 0.964473 View
ENSG00000134057 CCNB1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.964451 View
ENSG00000157764 BRAF ENSG00000170004 CHD3 H. sapiens SSL Slorth 0.964388 View
ENSG00000101868 POLA1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.964367 View
ENSG00000078747 ITCH ENSG00000157764 BRAF H. sapiens SSL Slorth 0.964336 View
ENSG00000004897 CDC27 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.964289 View
ENSG00000127586 CHTF18 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.964272 View
ENSG00000157764 BRAF ENSG00000198353 HOXC4 H. sapiens SDL Slorth 0.964254 View
ENSG00000073111 MCM2 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.964246 View
ENSG00000005007 UPF1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.964203 View
ENSG00000111875 ASF1A ENSG00000157764 BRAF H. sapiens SSL Slorth 0.964164 View
ENSG00000157764 BRAF ENSG00000186868 MAPT H. sapiens SDL Slorth 0.96414 View
ENSG00000128245 YWHAH ENSG00000157764 BRAF H. sapiens SSL Slorth 0.963988 View
ENSG00000157764 BRAF ENSG00000185896 LAMP1 H. sapiens SDL Slorth 0.963969 View
ENSG00000113456 RAD1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.963912 View
ENSG00000134853 PDGFRA ENSG00000157764 BRAF H. sapiens SSL Slorth 0.963837 View
ENSG00000157764 BRAF ENSG00000177606 JUN H. sapiens SSL Slorth 0.963807 View
ENSG00000157764 BRAF ENSG00000167085 PHB H. sapiens SSL Slorth 0.96377 View
ENSG00000157764 BRAF ENSG00000165731 RET H. sapiens SSL Slorth 0.9637 View
ENSG00000087191 PSMC5 ENSG00000157764 BRAF H. sapiens SDL Slorth 0.963633 View
ENSG00000157764 BRAF ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.963573 View
ENSG00000157764 BRAF ENSG00000166508 MCM7 H. sapiens SSL Slorth 0.963563 View
ENSG00000113575 PPP2CA ENSG00000157764 BRAF H. sapiens SDL Slorth 0.96343 View
ENSG00000157764 BRAF ENSG00000198793 MTOR H. sapiens SSL Slorth 0.963415 View
ENSG00000132383 RPA1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.963409 View
ENSG00000157764 BRAF ENSG00000166598 HSP90B1 H. sapiens SSL Slorth 0.963389 View
ENSG00000110092 CCND1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.963357 View
ENSG00000089159 PXN ENSG00000157764 BRAF H. sapiens SSL Slorth 0.963348 View
ENSG00000080815 PSEN1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.96332 View
ENSG00000132155 RAF1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.963157 View
ENSG00000154229 PRKCA ENSG00000157764 BRAF H. sapiens SDL Slorth 0.963148 View
ENSG00000004700 RECQL ENSG00000157764 BRAF H. sapiens SSL Slorth 0.962992 View
ENSG00000157764 BRAF ENSG00000169813 HNRNPF H. sapiens SSL Slorth 0.962881 View
ENSG00000157764 BRAF ENSG00000168283 BMI1 H. sapiens SSL Slorth 0.962833 View
ENSG00000136518 ACTL6A ENSG00000157764 BRAF H. sapiens SSL Slorth 0.962802 View
ENSG00000101966 XIAP ENSG00000157764 BRAF H. sapiens SDL Slorth 0.962776 View
ENSG00000157764 BRAF ENSG00000165416 SUGT1 H. sapiens SSL Slorth 0.96272 View
ENSG00000053900 ANAPC4 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.962695 View